hrp0089p1-p128 | Fat, Metabolism and Obesity P1 | ESPE2018

Rate of Accumulation of Abdominal Fat is Associated with Fasting Glucose Levels in Early Childhood

Anand Sadananthan Suresh , Thway Tint Mya , Michael Navin , Wei Pang Wei , Ling Loy See , Soh Shu-E , Shek Lynette , Yap Fabian , Hian Tan Kok , Kramer Michael , Eriksson Johan , Godfrey Keith , Gluckman Peter , Seng Chong Yap , Karnani Neerja , Seng Lee Yung , Fortier Marielle , Sendhil Velan S

Objectives: Abdominal fat has been strongly linked to increased cardiometabolic risk and impaired glucose regulation in adults. Owing to the lack of detailed body composition phenotyping in most previous child cohort studies, the temporal links between abdominal fat accumulation and impaired glucose regulation have not been well established. In this study, we evaluated the associations of abdominal fat assessed by MRI at early infancy (≤21 days after birth) and at 4.5 ye...

hrp0089p2-p153 | Fat, Metabolism and Obesity P2 | ESPE2018

Early BMI Trajectory Classes are Linked to Distinct Body Fat Partitioning Later in Childhood

Michael Navin , Ying Ong Yi , Sadananthan Suresh Anand , Aris Izzuddin M , Tint Mya Thway , Lun Wen Yuan , Wei Pang Wei , Ling Loy See , Soh Shu-E , Shek Lynette Pei-Chi , Yap Fabian Kok Peng , Tan Kok Hian , Godfrey Keith M , Gluckman Peter D , Chong Yap Seng , Karnani Neerja , Kramer Michael S , Eriksson Johan G , Fortier Marielle V , Velan S Sendhil , Lee Yung Seng

Background: Growth patterns in infancy and early childhood have been linked to risks of obesity and cardiometabolic disorders in adulthood. Body fat partitioning, particularly increased fat accumulation at ectopic sites, has been strongly associated with cardiometabolic disorders. However, the lack of precise body composition measures in prior longitudinal birth-cohort studies has made it difficult to ascertain if early growth patterns could result in consolidation of distinct...